Drama series depicting the frenetic daily lives of the doctors, nurses and patients in the hectic cardiac unit of Holby City General Hospital. The unit is run by the autocratic Consultant Surgeon Anton Meyer (George Irving) assisted by arrogant sidekick Registrar Nick (Michael French) who find themselves in a continuous running battle with Consultant Muriel McKendrick ('Phyllis Logan') over beds with the rest of the staff caught in the cross-fire.