A sound engineer's work for an Italian horror studio becomes a terrifying case of life imitating art.

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Riley searches for a cure to the virus that took over Samantha before it consumes him and the entire world.

During a rough period in her life, beautiful Samantha reluctantly decides to attend her best friend's party, and even though she still struggles with a previous addiction, she unwisely accepts a drink from a complete stranger. As a result, shortly after, hapless Samantha considerably inebriated, she will end up raped in the backseat of the malicious predator's car, however, from that point on, the terrible incident will be the least of her problems. Straight away and rather inexplicably, poor Samantha will begin noticing rapid and drastic organic changes in her body, and being unable to pinpoint the origin of the dramatic transformation, within the next 72 hours, she will embrace her gruesome and pitiless fate as well as the certainty that she is falling apart. Literally.

The moon rises at a predestined angle and awakens the sleeping Dr. Phibes three years later. To his dismay, he finds his house has been demolished and his papyrus scrolls stolen, the scrolls he needs to find the Pharoah's Tomb in Egypt, where the River of Life flows. After identifying the source of the papyrus theft, he packs and leaves for Egypt with his assistant Vulnavia, still intent upon awakening his dead wife Victoria. The parties responsible for the theft of Phibes' scrolls suffer an attrition problem as Inspector Trout chases him across the world.

A group of eight college friends gather together at an island mansion belonging to heiress Muffy St. John to celebrate their final year of school. They soon discover that each has a hidden secret from their past which is revealed, and soon after, they turn up dead. Yet, are they really dead? Or is it just part of some very real and cruel April Fool's jokes? The hostess, Muffy, is the only one who apparently knows what's going on. But then again, is it really her doing the killing?