A female werewolf runs away from her family, and falls in love with a man who works in the movie business, while a sociologist who studies these creatures is looking for proof of their existence.

Ellie has been taking care of her younger brother Jimmy since their parents death. One night after picking him up from a party they are involved in a car accident on Mullholland Drive. While trying to rescue a woman from the other car a creature attacks and kills her, also injuring both Ellie and Jimmy. After some research Jimmy realizes the creature could only have been a werewolf.

In a remote bar, a newcomer advises the customers to seal the place up, as hungry monsters will soon attack them. The customers must quickly organize a strategy to defend themselves from the deadly creatures.

In the Nineteenth Century, in Darkness Falls, Matilda Dixon is a good woman, who exchanges with children their baby teeth per coins. One day, her face is burnt in a fire in her house, she becomes sensitive to light and uses a china mask to protect her face against light. When two children are not found in the town, Matilda is blamed by the population and burnt in a fire, as if she were a witch. She claims to be not guilty and curses the whole population of the town and their descendants, stating that when each child loses the last tooth, she would come to get it, and if the child looks at her, she would kill him or her. After her death, the two children are found, and the shamed citizens decide to bury this sad and unfair event and never mention it again. Twelve years ago, the boy Kyle accidentally saw the Tooth Fairy, and she killed his mother. All the persons in Darkness Falls but his girlfriend Caitlin accused the boy of murdering his mother and sent him to an institution, considered deranged. In the present days, Caitlin calls Kyle to help her young brother Michael, who has seen the Fairy Tooth and is afraid of the dark.

In a red light district, newswoman Karen White is bugged by the police, investigating serial killer Eddie Quist, who has been molesting her through phone calls. After police officers find them in a peep-show cabin and shoot Eddie, Karen becomes emotionally disturbed and loses her memory. Hoping to conquer her inner demons, she heads for the Colony, a secluded retreat where the creepy residents are rather too eager to make her feel at home. There also seems to be a bizarre connection between Eddie Quist and this supposedly safe haven. And when, after nights of being tormented by unearthly cries, Karen ventures into the forest and makes a terrifying discovery.

On the eve of his high school graduation, unremarkable Will Kidman finally bonds with the girl he has long yearned for, reclusive Eliana Wynter. But he also discovers a dark secret from his past... that he is about to become a werewolf. Now, in an effort to fight destiny and save their love as well as their lives, they must battle not only Will's growing blood lust but an army of fearsome beasts bent on killing them... and then, us all.

After countless millennia of watching, waiting and stalking, the unholy creatures known as werewolves are poised to inherit the earth. After newswoman Karen White's shocking on-screen transformation and violent death, her brother Ben is approached by Stefan Crosscoe, a mysterious gentleman who claims that Karen has actually become a werewolf. But this is the least of their worries... To save mankind, Stefan and Ben must travel to Transylvania to battle and destroy Stirba, the immortal queen of all werewolves, before she is restored to her full powers!