Fashion designer Anita and computer-game writer Roger meet, fall in love and marry along with their dalmatians Perdita and Pongo. But the proud dogs' puppies are kidnapped by Anita's boss Cruella De Vil, who is stealing young dalmatians to make the coat she has set her heart on. Enlisting the help of the British animal kingdom, Pongo and Perdita set out to find and rescue all ninety-nine pups from their fearsome captors, Jasper and Horace.

In Japan, the Sicilian martial arts expert Nicolo "Nico" Toscani is recruited by the CIA Special Agent Nelson Fox to join the Special Operations Forces in the border of the Vietnam and Cambodia. In 1973, Nico witnesses the torturer Kurt Zagon interrogating prisoners of war and he is disgusted and quits the CIA, returning to Chicago. Fifteen years later, Nico is married with a baby with his wife Sarah and they live in the same house of his mother. Nico is a tough and incorruptible narcotics detective of the Chicago Police Department very close to his partner and friend Delores 'Jacks' Jackson and his friend Detective Lukich. When Nico and Jacks investigate a drug traffic operation, they arrest the gang of the drug dealer Tony Salvano but they find that they are smuggling the plastic explosive C4 instead. However there is an interference of the FBI and Salvano and his partner are released by FBI Agent Neeley (Nicholas Kusenko) and the detectives are forbidden of proceed with the investigation. But Nico does not stop and is suspended from the police force. But when there is an explosion in the church of his neighborhood and his friend and parish priest Joseph Gennaro is murdered, Nico chases Salvano and discovers a corruption ring that is planning to kill the American Senator Ernest Harrison that is investigating the involvement of the CIA with drug traffic.

Jericho "Action" Jackson is a Detroit police sergeant who was demoted from lieutenant for almost tearing the arm off of sexually violent sociopath Sean Dellaplane, whose father is Peter Dellaplane, a major car manufacturer. But Dellaplane himself is violent as well. Dellaplane kills his wife Patrice by shooting her. And then he plants her body in Jackson's apartment, framing Jackson. Dellaplane won't miss Patrice very much, because he has a drug-addicted mistress named Sydney Ash. He keeps Sydney hooked with a free supply of heroin. Jackson suspects Dellaplane of masterminding a murder spree against local officials from the auto workers' union. Dellaplane's mission is to gain a political power base and choose the next president of the United States. Because of what happened to Dellaplane's son Sean, Dellaplane has taken a particular dislike to Jackson. Jackson gets Sydney's help in going after Dellaplane.